Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of .ALPHA.,.GAMMA.-Diaminobutyric Acid Residues
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چکیده
منابع مشابه
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10 - 601 B Recitation 2
In this problem we illustrate how gradients can be used to solve the least squares problem. Suppose we have input data matrix X ∈ Rn×p, output data y ∈ R and weight vector w ∈ R, where p is the number of features per observation. The linear system Xw = y corresponds to choosing a weight vector w that perfectly predicts yi given X{i, :} for all observations i = 1, . . . , n. The least squares pr...
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15 صفحه اولFramework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus.
In the face of diminishing therapeutic options for the treatment of infections caused by multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and polymyxin B. These antibiotics became available clinically in the 1950s, when understanding of antimicrobial pharmacology and regulatory requirements for approval of drugs was substantially less than today. At the 1s...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2007
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.55.1724